Details

Autor(en) / Beteiligte

• Henry, Carole
• Zheng, Nai-Ying
• Huang, Min
• Cabanov, Alexandra
• Rojas, Karla Thatcher
• Kaur, Kaval
• Andrews, Sarah F.
• Palm, Anna-Karin E.
• Chen, Yao-Qing
• Li, Yang
• Hoskova, Katerina
• Utset, Henry A.
• Vieira, Marcos C.
• Wrammert, Jens
• Ahmed, Rafi
• Holden-Wiltse, Jeanne
• Topham, David J.
• Treanor, John J.
• Ertl, Hildegund C.
• Schmader, Kenneth E.
• Cobey, Sarah
• Krammer, Florian
• Hensley, Scott E.
• Greenberg, Harry
• He, Xiao-Song
• Wilson, Patrick C.

Titel

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Ist Teil von

• Cell host & microbe, 2019-03, Vol.25 (3), p.357-366.e6

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically distinct epitopes on emerging strains. We examined factors contributing to reduced influenza vaccine efficacy in the elderly and uncovered a dramatic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination. This reduction is associated with a significant decrease in the capacity of antibodies to target the viral glycoprotein, hemagglutinin (HA), and critical protective epitopes surrounding the HA receptor-binding domain. Immune escape by antigenic drift, in which viruses generate mutations in key antigenic epitopes, becomes highly exaggerated. Because of this reduced adaptability, most B cells activated in the elderly cohort target highly conserved but less potent epitopes. Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a priority to protect elderly individuals. [Display omitted] •Elderly adults have less de novo somatic hypermutations in immunoglobulin variable genes•Elderly individuals have less adaptability in their antibody responses to influenza•Antibodies from the elderly target conserved, often less potent hemagglutinin epitopes Influenza virus vaccination elicits poor efficacy in elderly individuals. Henry et al. find that elderly adults have a reduced accumulation of de novo immunoglobulin gene somatic mutations and are unable to adapt their antibody responses upon influenza virus vaccination. These results should be considered when designing vaccines for elderly populations.