Details

Autor(en) / Beteiligte

• Boyington, Allyson J
• Seath, Ciaran P
• Zearfoss, Avery M
• Xu, Zihao
• Jui, Nathan T

Titel

Catalytic Strategy for Regioselective Arylethylamine Synthesis

Ist Teil von

• Journal of the American Chemical Society, 2019-03, Vol.141 (9), p.4147-4153

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small molecules.