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Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives
Ist Teil von
Applied microbiology and biotechnology, 2019-03, Vol.103 (6), p.2525-2535
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Springer Journals
Beschreibungen/Notizen
Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as
Escherichia coli
,
Corynebacterium glutamicum
and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.