UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 19 von 33
Datensatz exportieren als...
BibTeX
Occupational exposure to diesel engine exhaust and serum cytokine levels
Environmental and molecular mutagenesis, 2018-03, Vol.59 (2), p.144-150
Dai, Yufei
Ren, Dianzhi
Bassig, Bryan A.
Vermeulen, Roel
Hu, Wei
Niu, Yong
Duan, Huawei
Ye, Meng
Meng, Tao
Xu, Jun
Bin, Ping
Shen, Meili
Yang, Jufang
Fu, Wei
Meliefste, Kees
Silverman, Debra
Rothman, Nathaniel
Lan, Qing
Zheng, Yuxin
2018
Details
Autor(en) / Beteiligte
Dai, Yufei
Ren, Dianzhi
Bassig, Bryan A.
Vermeulen, Roel
Hu, Wei
Niu, Yong
Duan, Huawei
Ye, Meng
Meng, Tao
Xu, Jun
Bin, Ping
Shen, Meili
Yang, Jufang
Fu, Wei
Meliefste, Kees
Silverman, Debra
Rothman, Nathaniel
Lan, Qing
Zheng, Yuxin
Titel
Occupational exposure to diesel engine exhaust and serum cytokine levels
Ist Teil von
Environmental and molecular mutagenesis, 2018-03, Vol.59 (2), p.144-150
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
The International Agency for Research on Cancer has classified diesel engine exhaust (DEE) as a human lung carcinogen. Given that inflammation is suspected to be an important underlying mechanism of lung carcinogenesis, we evaluated the relationship between DEE exposure and the inflammatory response using data from a cross‐sectional molecular epidemiology study of 41 diesel engine testing workers and 46 unexposed controls. Repeated personal exposure measurements of PM2.5 and other DEE constituents were taken for the diesel engine testing workers before blood collection. Serum levels of six inflammatory biomarkers including interleukin (IL)‐1, IL‐6, IL‐8, tumor necrosis factor (TNF)‐α, macrophage inflammatory protein (MIP)‐1β, and monocyte chemotactic protein (MCP)‐1 were analyzed in all subjects. Compared to unexposed controls, concentrations of MIP‐1β were significantly reduced by ∼37% in DEE exposed workers (P < 0.001) and showed a strong decreasing trend with increasing PM2.5 concentrations in all subjects (Ptrend < 0.001) as well as in exposed subjects only (Ptrend = 0.001). Levels of IL‐8 and MIP‐1β were significantly lower in workers in the highest exposure tertile of PM2.5 (>397 µg/m3) compared to unexposed controls. Further, significant inverse exposure‐response relationships for IL‐8 and MCP‐1 were also found in relation to increasing PM2.5 levels among the DEE exposed workers. Given that IL‐8, MIP‐1β, and MCP‐1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.5 exposure may provide insight into the mechanism by which DEE promotes lung cancer. Environ. Mol. Mutagen. 59:144–150, 2018. © 2017 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0893-6692
eISSN: 1098-2280
DOI: 10.1002/em.22142
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6438621
Format
–
Schlagworte
Air Pollutants, Occupational - toxicity
,
Biomarkers
,
Cancer
,
Carcinogenesis
,
Carcinogens
,
Chemokine CCL2 - blood
,
Chemokine CCL4 - blood
,
Chemokines
,
Cytokines - blood
,
Cytokines - drug effects
,
Diesel
,
diesel engine exhaust
,
Diesel engines
,
Dose-response effects
,
Epidemiology
,
Exhaust emissions
,
Exposure
,
Female
,
Humans
,
Immune clearance
,
Immune system
,
Inflammation
,
inflammatory biomarkers
,
Inflammatory response
,
Interleukin
,
Interleukin 1
,
Interleukin 6
,
Interleukin 8
,
Interleukin-1 - blood
,
Interleukin-6 - blood
,
Interleukin-8 - blood
,
Lung cancer
,
Lung Neoplasms - blood
,
Lung Neoplasms - chemically induced
,
Macrophage inflammatory protein
,
Macrophages
,
Male
,
molecular epidemiology
,
Monocyte chemoattractant protein 1
,
Occupational exposure
,
Occupational health
,
Particulate matter
,
Serum levels
,
Tumor necrosis factor
,
Tumor Necrosis Factor-alpha - blood
,
Tumor necrosis factor-TNF
,
Vehicle Emissions - toxicity
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX