Details

Autor(en) / Beteiligte

• Nathan, David M.
• Knowler, William C.
• Edelstein, Sharon
• Crandall, Jill P.
• Dabelea, Dana
• Goldberg, Ronald B.
• Kahn, Steven E.
• Mather, Kieren J.
• Trandafirescu, Gilda
• Walker, Elizabeth A.
• Temprosa, Marinella
• Bray, George A.
• Gadde, Kishore
• Chatellier, Annie
• Arceneaux, Jennifer
• Dragg, Amber
• Duncan, Crystal
• Greenway, Frank L.
• Hsia, Daniel
• Levy, Erma
• Lockett, Monica
• Ryan, Donna H.
• Ehrmann, David
• Matulik, Margaret J.
• Czech, Kirsten
• DeSandre, Catherine
• Goldstein, Barry J.
• Furlong, Kevin
• Smith, Kellie A.
• Wildman, Wendi
• Pepe, Constance
• Calles, Jeanette
• Ojito, Juliet
• Castillo-Florez, Sumaya
• Giannella, Anna
• Lara, Olga
• Veciana, Beth
• Haffner, Steven M.
• Hazuda, Helen P.
• Montez, Maria G.
• Hattaway, Kathy
• Lorenzo, Carlos
• Martinez, Arlene
• Walker, Tatiana
• Hamman, Richard F.
• Testaverde, Lisa
• Anderson, Denise
• Bouffard, Alexis
• Jenkins, Tonya
• Lenz, Dione
• Perreault, Leigh
• Price, David W.
• Steinke, Sheila C.
• Horton, Edward S.
• Poirier, Catherine S.
• Swift, Kati
• Caballero, Enrique
• Fargnoli, Barbara
• Guidi, Ashley
• Guido, Mathew
• Jackson, Sharon D.
• Lambert, Lori
• Lawton, Kathleen E.
• Ledbury, Sarah
• Sansoucy, Jessica
• Spellman, Jeanne
• Montgomery, Brenda K.
• Fujimoto, Wilfred
• Knopp, Robert H.
• Lipkin, Edward W.
• Morgan-Taggart, Ivy
• Murillo, Anne
• Taylor, Lonnese
• Thomas, April
• Tsai, Elaine C.
• Trence, Dace
• Kitabchi, Abbas E.
• Dagogo-Jack, Samuel
• Murphy, Mary E.
• Taylor, Laura
• Dolgoff, Jennifer
• Clark, Debra
• Ibebuogu, Uzoma
• Lambeth, Helen
• Ricks, Harriet
• Rutledge, Lily M.K.
• Soberman, Judith E.
• Molitch, Mark E.
• Metzger, Boyd E.
• Johnson, Mariana K.
• Giles, Mimi M.
• Larsen, Diane
• Pen, Samsam C.
• Larkin, Mary
• McKitrick, Charles
• Turgeon, Heather
• Anderson, Ellen
• Bissett, Laurie
• Bondi, Kristy
• Cagliero, Enrico

Titel

Long-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study

Ist Teil von

• Diabetes care, 2019-04, Vol.42 (4), p.601-608

Ort / Verlag

United States: American Diabetes Association

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS). During the DPP (1996-2001), adults at high risk of developing diabetes were randomly assigned to masked placebo ( = 1,082) or metformin 850 mg twice daily ( = 1,073). Participants originally assigned to metformin continued to receive metformin, unmasked, in the DPPOS (2002-present). Ascertainment of diabetes development was based on fasting or 2-h glucose levels after an oral glucose tolerance test or on HbA . Reduction in diabetes incidence with metformin was compared with placebo in subgroups by hazard ratio (HR) and rate differences (RDs). During 15 years of postrandomization follow-up, metformin reduced the incidence (by HR) of diabetes compared to placebo by 17% or 36% based on glucose or HbA levels, respectively. Metformin's effect on the development of glucose-defined diabetes was greater for women with a history of prior gestational diabetes mellitus (GDM) (HR 0.59, RD -4.57 cases/100 person-years) compared with parous women without GDM (HR 0.94, RD -0.38 cases/100 person-years [interaction = 0.03 for HR, = 0.01 for RD]). Metformin also had greater effects, by HR and RD, at higher baseline fasting glucose levels. With diabetes development based on HbA , metformin was more effective in subjects with higher baseline HbA by RD, with metformin RD -1.03 cases/100 person-years with baseline HbA <6.0% (42 mmol/mol) and -3.88 cases/100 person-years with 6.0-6.4% ( = 0.0001). Metformin reduces the development of diabetes over 15 years. The subsets that benefitted the most include subjects with higher baseline fasting glucose or HbA and women with a history of GDM.