Details

Autor(en) / Beteiligte

• Komohara, Yoshihiro
• Noyori, Osamu
• Saito, Yoichi
• Takeya, Hiroto
• Baghdadi, Muhammad
• Kitagawa, Fumihito
• Hama, Naoki
• Ishikawa, Kozo
• Okuno, Yutaka
• Nosaka, Kisato
• Seino, Ken-ichiro
• Matsuoka, Masao
• Suzu, Shinya

Titel

Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma

Ist Teil von

• Journal of Clinical and Experimental Hematopathology, 2018, Vol.58(4), pp.152-160

Ort / Verlag

Japan: The Japanese Society for Lymphoreticular Tissue Research

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The c-fms proto-oncogene is also known as macrophage colony stimulating factor receptor (M-CSFR) or colony-stimulating factor-1 receptor (CSF-1R), and is expressed on several types of malignant tumor cells and myeloid cells. In the present study, we found that overexpression of M-CSFR was present in adult T-cell leukemia/lymphoma (ATLL) cases. M-CSFR signaling was associated with lymphoma cell proliferation, and M-CSFR inhibition induced apoptosis in lymphoma cells. The ATLL cell line ATL-T expressed M-CSF/CSF-1 and interleukin (IL)-34, which are both M-CSFR ligands. M-CSF and IL-34 expression was seen in ATLL cases, and co-expression of these ligands was detected in 11 of 13 ATLL cases. M-CSFR inhibition suppressed programmed death-1 and -2 ligand in ATL-T cells and macrophages stimulated with conditioned medium from ATL-T cells. Thus, an M-CSFR inhibitor may be useful as additional therapy against ATLL due to direct and indirect mechanisms.