Chemical reviews, 2019-01, Vol.119 (2), p.1323-1455
2019
Details
- Autor(en) / Beteiligte
- Titel
- Targeting Metalloenzymes for Therapeutic Intervention
- Ist Teil von
- Chemical reviews, 2019-01, Vol.119 (2), p.1323-1455
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2665, 1520-6890eISSN: 1520-6890DOI: 10.1021/acs.chemrev.8b00201Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6405328
- Format
- –
- Schlagworte
- Carbonic Anhydrases - chemistry, Carbonic Anhydrases - metabolism, Catalytic Domain, Drug Discovery, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - metabolism, Enzyme Inhibitors - therapeutic use, Enzymes, Intervention, Matrix Metalloproteinases - chemistry, Matrix Metalloproteinases - metabolism, Metalloproteins - antagonists & inhibitors, Metalloproteins - metabolism, Oxidoreductases - antagonists & inhibitors, Oxidoreductases - metabolism, Peptide Hydrolases - chemistry, Peptide Hydrolases - metabolism, Proteins, R&D, Research & development, Transferases - antagonists & inhibitors, Transferases - metabolism, Virus Diseases - drug therapy