Details

Autor(en) / Beteiligte

• HORI, Yasutomo
• TAIRA, Hiroto
• NAKAJIMA, Yuji
• ISHIKAWA, Yusyun
• YUMOTO, Yuki
• MAEKAWA, Yuya
• OSHIRO, Akiko

Titel

Inotropic effects of a single intravenous recommended dose of pimobendan in healthy dogs

Ist Teil von

• Journal of Veterinary Medical Science, 2019, Vol.81(1), pp.22-25

Ort / Verlag

Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• We investigated the effects of an injectable pimobendan solution (0.15 mg/kg) on cardiac function in healthy dogs. Fifteen dogs were divided into placebo, intravenous pimobendan injection, and subcutaneous pimobendan injection groups. In the placebo, the heart rate, systolic and end-diastolic left ventricular pressure (LVPs and LVEDP), and peak positive (max dP/dt) and negative (min dP/dt) first derivatives of the left ventricular pressure did not change for 60 min. After the intravenous pimobendan injection, LVEDP decreased significantly within 5 min, while the max dP/dt increased, and the effects continued until 60 min. In comparison, there were no hemodynamic changes after the subcutaneous pimobendan injection. This study demonstrates that injectable pimobendan induced a rapid inotropic effect and decreased the LVEDP in dogs.