Euro surveillance : bulletin européen sur les maladies transmissibles, 2019-01, Vol.24 (3), p.1
2019
Details
- Autor(en) / Beteiligte
- Titel
- Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons
- Ist Teil von
- Euro surveillance : bulletin européen sur les maladies transmissibles, 2019-01, Vol.24 (3), p.1
- Ort / Verlag
- Sweden: Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4-10-fold reduced susceptibility to baloxavir.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1560-7917, 1025-496XeISSN: 1560-7917DOI: 10.2807/1560-7917.es.2019.24.3.1800666Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6344838
- Format
- –
- Schlagworte
- Amino Acid Substitution - drug effects, Amino Acid Substitution - genetics, Antiviral Agents - pharmacology, Antiviral Agents - therapeutic use, Dibenzothiepins, Drug Resistance, Viral - genetics, Drug therapy, Enzyme Inhibitors - pharmacology, Humans, Immunization, Influenza, Influenza A Virus, H1N1 Subtype - genetics, Influenza A Virus, H3N2 Subtype - drug effects, Influenza A Virus, H3N2 Subtype - genetics, Influenza A Virus, H3N2 Subtype - isolation & purification, Influenza B virus - drug effects, Influenza B virus - genetics, Influenza B virus - isolation & purification, Influenza, Human - drug therapy, Influenza, Human - epidemiology, Influenza, Human - virology, Microbial Sensitivity Tests, Morpholines, Oxazines - pharmacology, Pyridines - pharmacology, Pyridones, Rapid Communication, Seasons, Sentinel Surveillance, Thiepins - pharmacology, Triazines - pharmacology, United States, Viral Proteins - genetics, Viruses