Details

Autor(en) / Beteiligte

• Kruger, Tillmann H C
• Sinke, Christopher
• Kneer, Jonas
• Tenbergen, Gilian
• Khan, Abdul Qayyum
• Burkert, Alexandra
• Müller-Engling, Linda
• Engler, Harald
• Gerwinn, Hannah
• von Wurmb-Schwark, Nicole
• Pohl, Alexander
• Weiß, Simone
• Amelung, Till
• Mohnke, Sebastian
• Massau, Claudia
• Kärgel, Christian
• Walter, Martin
• Schiltz, Kolja
• Beier, Klaus M
• Ponseti, Jorge
• Schiffer, Boris
• Walter, Henrik
• Jahn, Kirsten
• Frieling, Helge

Titel

Child sexual offenders show prenatal and epigenetic alterations of the androgen system

Ist Teil von

• Translational psychiatry, 2019-01, Vol.9 (1), p.28-28, Article 28

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Child sexual offending (CSO) places a serious burden on society and medicine and pedophilia (P) is considered a major risk factor for CSO. The androgen system is closely linked to sexual development and behavior. This study assessed markers of prenatal brain androgenization, genetic parameters of androgen receptor function, epigenetic regulation, and peripheral hormones in a 2 × 2 factorial design comprising the factors Offense (yes/no) and Pedophilia (yes/no) in analyzing blood samples from 194 subjects (57 P+CSO, 45 P-CSO, 20 CSO-P, and 72 controls) matched for age and intelligence. Subjects also received a comprehensive clinical screening. Independent of their sexual preference, child sexual offenders showed signs of elevated prenatal androgen exposure compared with non-offending pedophiles and controls. The methylation status of the androgen receptor gene was also higher in child sexual offenders, indicating lower functionality of the testosterone system, accompanied by lower peripheral testosterone levels. In addition, there was an interaction effect on methylation levels between offense status and androgen receptor functionality. Notably, markers of prenatal androgenization and the methylation status of the androgen receptor gene were correlated with the total number of sexual offenses committed. This study demonstrates alterations of the androgen system on a prenatal, epigenetic, and endocrine level. None of the major findings was specific for pedophilia, but they were for CSO. The findings support theories of testosterone-linked abnormalities in early brain development in delinquent behavior and suggest possible interactions of testosterone receptor gene methylation and plasma testosterone with environmental factors.