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Obesity (Silver Spring, Md.), 2018-11, Vol.26 (11), p.1796-1806
2018
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Details

Autor(en) / Beteiligte
Titel
BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization
Ist Teil von
  • Obesity (Silver Spring, Md.), 2018-11, Vol.26 (11), p.1796-1806
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2018
Quelle
MEDLINE
Beschreibungen/Notizen
  • Objective The aim of this study was to obtain estimates of the causal relationship between BMI and mortality. Methods Mendelian randomization (MR) with BMI‐associated genotypic variation was used to test the causal effect of BMI on all‐cause and cause‐specific mortality in UK Biobank participants of White British ancestry. Results MR analyses supported a causal association between higher BMI and greater risk of all‐cause mortality (hazard ratio [HR] per 1 kg/m2: 1.03; 95% CI: 0.99‐1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01‐1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00‐1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03‐1.48), stomach cancer (HR: 1.18; 95% CI: 0.87‐1.62), and esophageal cancer (HR: 1.22; 95% CI: 0.98‐1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95% CI: 0.85‐1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J‐shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range. Conclusions Results support a causal role of higher BMI in increasing the risk of all‐cause mortality and mortality from several specific causes.
Sprache
Englisch
Identifikatoren
ISSN: 1930-7381
eISSN: 1930-739X
DOI: 10.1002/oby.22313
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6334168

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