Details

Autor(en) / Beteiligte

• Baranov, Sergei V.
• Baranova, Oxana V.
• Yablonska, Svitlana
• Suofu, Yalikun
• Vazquez, Alberto L.
• Kozai, Takashi D. Y.
• Cui, X. Tracy
• Ferrando, Lisa M.
• Larkin, Timothy M.
• Tyurina, Yulia Y.
• Kagan, Valerian E.
• Carlisle, Diane L.
• Kristal, Bruce S.
• Friedlander, Robert M.

Titel

Mitochondria modulate programmed neuritic retraction

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (2), p.650-659

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Neuritic retraction in the absence of overt neuronal death is a shared feature of normal aging and neurodegenerative disorders, but the intracellular mechanisms modulating this process are not understood. We propose that cumulative distal mitochondrial protein damage results in impaired protein import, leading to mitochondrial dysfunction and focal activation of the canonical apoptosis pathway in neurites. This is a controlled process that may not lead to neuronal death and, thus, we term this phenomenon “neuritosis.” Consistent with our hypothesis, we show that in primary cerebrocortical neurons, mitochondrial distance from the soma correlates with increased mitochondrial protein damage, PINK1 accumulation, reactive oxygen species production, and decreased mitochondrial membrane potential and depolarization threshold. Furthermore, we demonstrate that the distance-dependent mitochondrial membrane potential gradient exists in vivo in mice. We demonstrate that impaired distal mitochondria have a lower threshold for focal/nonlethal neuritic caspase-3 activation in normal neurons that is exacerbated in aging, stress, and neurodegenerative conditions, thus delineating a fundamental mechanistic underpinning for synaptic vulnerability.