Details

Autor(en) / Beteiligte

• Finkel, Toren
• Menazza, Sara
• Holmström, Kira M
• Parks, Randi J
• Liu, Julia
• Sun, Junhui
• Liu, Jie
• Pan, Xin
• Murphy, Elizabeth

Titel

The Ins and Outs of Mitochondrial Calcium

Ist Teil von

• Circulation research, 2015-05, Vol.116 (11), p.1810-1819

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Calcium is thought to play an important role in regulating mitochondrial function. Evidence suggests that an increase in mitochondrial calcium can augment ATP production by altering the activity of calcium-sensitive mitochondrial matrix enzymes. In contrast, the entry of large amounts of mitochondrial calcium in the setting of ischemia-reperfusion injury is thought to be a critical event in triggering cellular necrosis. For many decades, the details of how calcium entered the mitochondria remained a biological mystery. In the past few years, significant progress has been made in identifying the molecular components of the mitochondrial calcium uniporter complex. Here, we review how calcium enters and leaves the mitochondria, the growing insight into the topology, stoichiometry and function of the uniporter complex, and the early lessons learned from some initial mouse models that genetically perturb mitochondrial calcium homeostasis.