Details

Autor(en) / Beteiligte

• Son, Heehwa G
• Seo, Keunhee
• Seo, Mihwa
• Park, Sangsoon
• Ham, Seokjin
• An, Seon Woo A
• Choi, Eun-Seok
• Lee, Yujin
• Baek, Haeshim
• Kim, Eunju
• Ryu, Youngjae
• Ha, Chang Man
• Hsu, Ao-Lin
• Roh, Tae-Young
• Jang, Sung Key
• Lee, Seung-Jae V

Titel

Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

Ist Teil von

• Genes & development, 2018-12, Vol.32 (23-24), p.1562-1575

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In , HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.