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This overview of 200 years of research and progress in the field of cancer provides support for the value of patience and investment in research.
In the 200 years since the
New England Journal of Medicine
was founded, cancer has gone from a black box to a blueprint. During the first century of the
Journal
's publication, medical practitioners could observe tumors, weigh them, and measure them but had few tools to examine the workings within the cancer cell. A few astute observers were ahead of their time, including Rudolf Virchow, who with the benefit of a microscope deduced the cellular origin of cancer in 1863,
1
and Stephen Paget, who in 1889 wisely mused about the seed-and-soil hypothesis of metastatic disease,
2
a theory that is . . .