Details

Autor(en) / Beteiligte

• Huang, Jia
• Xia, Chun
• Zheng, Xin
• Yi, Ting
• Wang, Xiao
• Song, Gang
• Zhang, Bing

Titel

17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway

Ist Teil von

• Cellular & molecular biology letters, 2011-12, Vol.16 (4), p.564-575

Ort / Verlag

England: Versita

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Osteoarthritis (OA) is the most common cause of musculoskeletal pain and disability. The importance of chondrocytes in the pathogenesis of OA is unequivocal. 17β-estradiol (E2) has a potential protective effect against OA. However, the mechanism of E2 in OA chondrocytes remains unclear. In this study, we investigated the regulative effect of E2 on cell growth and the relationship between E2 and the PI3K/Akt pathway in rat OA model chondrocytes (pretreated with interleukin-1β). We found that E2 induced chondrocyte proliferation, and increased the expression level of Akt simultaneously, especially the expression level of P-Akt. Furthermore, the inhibition of P-Akt could block chondrocyte proliferation induced by E2. These results suggest that PI3K/Akt activation induced by E2 may be an important factor in the mechanism of E2 in cell proliferation in rat OA model chondrocytes, and help further understanding the role of E2 in OA progression.