Advanced materials (Weinheim), 2016-09, Vol.28 (36), p.7962-7969
2016
Details
- Autor(en) / Beteiligte
- Titel
- Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain
- Ist Teil von
- Advanced materials (Weinheim), 2016-09, Vol.28 (36), p.7962-7969
- Ort / Verlag
- Germany: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell‐penetrating peptides attached to the calcium silicate shell.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0935-9648eISSN: 1521-4095DOI: 10.1002/adma.201600634Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6274592
- Format
- –
- Schlagworte
- Animals, Brain, Brain - metabolism, Brain - pathology, Brain Injuries - metabolism, Brain Injuries - pathology, Calcium Compounds - chemistry, Calcium ions, Calcium silicates, Cell Line, Tumor, Disease Models, Animal, gene knockdowns, Genes, injured brains, Mice, Nanoparticles, Nanoparticles - chemistry, Payloads, photoluminescence, Porosity, Porous silicon, rabies virus glycoprotein peptides, RNA, Small Interfering - administration & dosage, RNA, Small Interfering - metabolism, RNA, Small Interfering - pharmacokinetics, Silicates, Silicates - chemistry, Silicon - chemistry, targeted nanoparticles