Details

Autor(en) / Beteiligte

• Kwasniewski, Wojciech
• Wolun-Cholewa, Maria
• Kotarski, Jan
• Warchol, Wojciech
• Kuzma, Dorota
• Kwasniewska, Anna
• Gozdzicka-Jozefiak, Anna

Titel

Microbiota dysbiosis is associated with HPV-induced cervical carcinogenesis

Ist Teil von

• Oncology letters, 2018-12, Vol.16 (6), p.7035-7047

Ort / Verlag

Greece: Spandidos Publications

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Cervical microbial communities serve a crucial role in the persistence and development of oncogenic human papilloma virus (HPV) infections. In the present study, the authors hypothesised that disturbed heterogeneity of microbial flora was associated with HPV-induced carcinogenesis. Swabs of the cervical microbiota were collected from 250 women and the 16S ribosomal DNA was sequenced using a high throughput assay. The swabs of cervical microbiota were grouped according to the community state types (CSTs) as follows: Healthy cervical swabs; swabs taken from low-grade squamous intra-epithelial lesions (LSIL) and swabs taken from high-grade squamous intra-epithelial lesions (HSIL). Analysis of the bacterial classes revealed that the CST cervical swabs of the volunteers were characterised by and , however, and were absent. In the CST of patients with LSIL the predominant type of bacteria was and , however was not detected. Swabs from CST women diagnosed with HSIL exhibited abundant and , however, lacked and . The abundance of in swabs from the healthy women was compared with the swabs from the women with LSIL. The results of the present study indicated that the development of HPV-induced cancer is associated with a high diversity of vaginal microbiota, which is involved in the control of viral persistence, and is therefore indicative of disease prognosis.