Cell, 2018-11, Vol.175 (5), p.1289-1306.e20
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
- Ist Teil von
- Cell, 2018-11, Vol.175 (5), p.1289-1306.e20
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report that NASH and fibrosis and HCC in obesity can be dissociated. We show that the oxidative hepatic environment in obesity inactivates the STAT-1 and STAT-3 phosphatase T cell protein tyrosine phosphatase (TCPTP) and increases STAT-1 and STAT-3 signaling. TCPTP deletion in hepatocytes promoted T cell recruitment and ensuing NASH and fibrosis as well as HCC in obese C57BL/6 mice that normally do not develop NASH and fibrosis or HCC. Attenuating the enhanced STAT-1 signaling prevented T cell recruitment and NASH and fibrosis but did not prevent HCC. By contrast, correcting STAT-3 signaling prevented HCC without affecting NASH and fibrosis. TCPTP-deletion in hepatocytes also markedly accelerated HCC in mice treated with a chemical carcinogen that promotes HCC without NASH and fibrosis. Our studies reveal how obesity-associated hepatic oxidative stress can independently contribute to the pathogenesis of NASH, fibrosis, and HCC. [Display omitted] •Obesity promotes hepatic STAT-1 and STAT-3 signaling•Obesity promotes STAT-1-dependent T cell-infiltration, NASH, and fibrosis•Obesity promotes NASH-independent STAT-3-dependent HCC Independent pathways contribute to development of NASH and hepatocellular carcinoma, disentangling the pathologies and providing insight for cancer treatments distinct from liver disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0092-8674eISSN: 1097-4172DOI: 10.1016/j.cell.2018.09.053Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6242467
- Format
- –
- Schlagworte
- Animals, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - metabolism, Diet, High-Fat, Disease Models, Animal, fibrosis, hepatocellular carcinoma, Hepatocytes - metabolism, Humans, Liver - metabolism, Liver - pathology, Liver Cirrhosis - metabolism, Liver Cirrhosis - pathology, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, Mice, Mice, Inbred C57BL, Mice, Knockout, Non-alcoholic Fatty Liver Disease - metabolism, Non-alcoholic Fatty Liver Disease - pathology, non-alcoholic steatohepatitis, nonalcoholic fatty liver disease, obesity, Obesity - metabolism, Obesity - pathology, Oxidative Stress, protein tyrosine phosphatase, Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency, Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics, Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism, PTPN2, Signal Transduction, STAT-1, STAT-3, STAT1 Transcription Factor - metabolism, STAT3 Transcription Factor - metabolism, T cells