Details

Autor(en) / Beteiligte

• Buchan, Gregory J.
• Bonacci, Gustavo
• Fazzari, Marco
• Salvatore, Sonia R.
• Gelhaus Wendell, Stacy

Titel

Nitro-fatty acid formation and metabolism

Ist Teil von

• Nitric oxide, 2018-09, Vol.79, p.38-44

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites. •Nitro-Fatty Acid (NO2-FA) formation is highly dependent on environmental factors including pH, PO2 and reactive species.•NO2-cLA is the most abundant, endogenous NO2-FA.•NO2-cLA is generated during metabolism and under conditions of inflammatory stress.•Absolute measurement of NO2-FA is complicated by protein adduction, metabolism and incorporation into complex lipids.