UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 7 von 31
Datensatz exportieren als...
BibTeX
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
Movement disorders, 2018-10, Vol.33 (10), p.1580-1590
Smith, Amy M.
Depp, Constanze
Ryan, Brent J.
Johnston, Geoffrey I.
Alegre‐Abarrategui, Javier
Evetts, Samuel
Rolinski, Michal
Baig, Fahd
Ruffmann, Claudio
Simon, Anna Katharina
Hu, Michele T. M.
Wade‐Martins, Richard
2018
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Smith, Amy M.
Depp, Constanze
Ryan, Brent J.
Johnston, Geoffrey I.
Alegre‐Abarrategui, Javier
Evetts, Samuel
Rolinski, Michal
Baig, Fahd
Ruffmann, Claudio
Simon, Anna Katharina
Hu, Michele T. M.
Wade‐Martins, Richard
Titel
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
Ist Teil von
Movement disorders, 2018-10, Vol.33 (10), p.1580-1590
Ort / Verlag
United States: John Wiley and Sons Inc
Erscheinungsjahr
2018
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
ABSTRACT Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD patients and rapid eye movement‐sleep behavior disorder patients who have a greatly increased risk of developing PD. We hypothesized that peripheral blood mononuclear cells may recapitulate cellular pathology found in the PD brain and investigated these cells for mitochondrial dysfunction and oxidative stress. Methods: Peripheral blood mononuclear cells were isolated and studied from PD patients, rapid eye movement‐sleep behavior disorder patients and age‐ and sex‐matched control individuals from the well‐characterized Oxford Discovery cohort. All participants underwent thorough clinical assessment. Results: Initial characterization showed that PD patients had elevated levels of CD14 + monocytes and monocytes expressing C‐C motif chemokine receptor 2. Mitochondrial dysfunction and oxidative stress were increased in PD patient peripheral blood mononuclear cells, with elevated levels of mitochondrial reactive oxygen species specifically in patient monocytes. This was combined with reduced levels of the antioxidant superoxide dismutase in blood cells from PD patients and, importantly, also in rapid eye movement‐sleep behavior disorder patients. This mitochondrial dysfunction was associated with a concomitant increase in glycolysis in both PD and rapid eye movement‐sleep behavior disorder patient blood cells independent of glucose uptake or monocyte activation. Conclusions: This work demonstrates functional bioenergetic deficits in PD and rapid eye movement‐sleep behavior disorder patient blood cells during the early stages of human disease. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.104
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6221131
Format
–
Schlagworte
Case-Control Studies
,
Cytokines - metabolism
,
Electron Transport Complex IV - metabolism
,
Enzyme Inhibitors - pharmacology
,
Female
,
Flow Cytometry
,
Gene Expression Regulation - drug effects
,
Gene Expression Regulation - genetics
,
Glucose - metabolism
,
Glucose Transporter Type 1 - metabolism
,
glycolysis
,
Glycolysis - physiology
,
Humans
,
Leukocytes, Mononuclear - ultrastructure
,
Male
,
Mitochondria - metabolism
,
Mitochondria - pathology
,
Mitochondrial Diseases - etiology
,
mitochondrial dysfunction
,
Oxygen Consumption - physiology
,
Parkinson Disease - blood
,
Parkinson Disease - complications
,
Parkinson Disease - pathology
,
Parkinson's disease
,
peripheral blood mononuclear cells
,
Prodromal Symptoms
,
Reactive Oxygen Species - metabolism
,
Receptors, CCR2 - metabolism
,
REM Sleep Behavior Disorder - blood
,
REM Sleep Behavior Disorder - complications
,
REM Sleep Behavior Disorder - pathology
,
REM‐sleep behavior disorder
,
RNA, Messenger - metabolism
,
Superoxide Dismutase - genetics
,
Superoxide Dismutase - metabolism
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX