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Neonatal Growth Restriction Slows Cardiomyocyte Development and Reduces Adult Heart Size
Anatomical record (Hoboken, N.J. : 2007), 2018-08, Vol.301 (8), p.1398-1404
Knott, Madeline H.
Haskell, Sarah E.
Strawser, Payton E.
Rice, Olivia M.
Bonthius, Natalie T.
Movva, Vani C.
Reinking, Benjamin E.
Roghair, Robert D.
2018
Details
Autor(en) / Beteiligte
Knott, Madeline H.
Haskell, Sarah E.
Strawser, Payton E.
Rice, Olivia M.
Bonthius, Natalie T.
Movva, Vani C.
Reinking, Benjamin E.
Roghair, Robert D.
Titel
Neonatal Growth Restriction Slows Cardiomyocyte Development and Reduces Adult Heart Size
Ist Teil von
Anatomical record (Hoboken, N.J. : 2007), 2018-08, Vol.301 (8), p.1398-1404
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
ABSTRACT Prematurity is associated with reduced cardiac dimensions and an increased risk of cardiovascular disease. While prematurity is typically associated with ex utero neonatal growth restriction (GR), the independent effect of neonatal GR on cardiac development has not been established. We tested the hypothesis that isolated neonatal GR decreases cardiomyocyte growth and proliferation, leading to long‐term alterations in cardiac morphology. C57BL/6 mice were fostered in litters ranging in size from 6 to 12 pups to accentuate normal variation in neonatal growth. Regardless of litter size, GR was defined by a weight below the 10th percentile. On postnatal day 8, Ki67 immunoreactivity, cardiomyocyte nucleation status and cardiomyocyte profile area were assessed. For adult mice, cardiomyocyte area was determined, along with cardiac dimensions by echocardiography and cardiac fibrosis by Masson's trichrome stain. On day 8, cardiomyocytes from GR versus control mice were significantly smaller and less likely to be binucleated with evidence of persistent cell cycle activity. As adults, GR mice continued to have smaller cardiomyocytes, as well as decreased left ventricular volumes without signs of fibrosis. Neonatal GR reduces cardiomyocyte size, delays the completion of binucleation, and leads to long‐term alterations in cardiac morphology. Clinical studies are needed to ascertain whether these results translate to preterm infants that must continue to grow and mature in the midst of the increased circulatory demands that accompany their premature transition to an ex utero existence. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1932-8486
eISSN: 1932-8494
DOI: 10.1002/ar.23851
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6218323
Format
–
Schlagworte
Age Factors
,
Animals
,
Animals, Newborn
,
Body Weight - physiology
,
cardiac development
,
cardiomyocyte
,
Cardiomyocytes
,
Cardiovascular diseases
,
Cell cycle
,
Echocardiography
,
Female
,
Fibrosis
,
growth
,
Heart - growth & development
,
Immunoreactivity
,
Infants
,
left ventricle
,
Male
,
Mice
,
Mice, Inbred C57BL
,
Morphology
,
Myocytes, Cardiac
,
Neonates
,
Organ Size - physiology
,
Organogenesis - physiology
,
prematurity
,
Ventricle
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