Details

Autor(en) / Beteiligte

• Kumar, Arnav
• Hung, Olivia Y.
• Piccinelli, Marina
• Eshtehardi, Parham
• Corban, Michel T.
• Sternheim, David
• Yang, Boyi
• Lefieux, Adrien
• Molony, David S.
• Thompson, Elizabeth W.
• Zeng, Wenjie
• Bouchi, Yasir
• Gupta, Sonu
• Hosseini, Hossein
• Raad, Mohamad
• Ko, Yi-An
• Liu, Chang
• McDaniel, Michael C.
• Gogas, Bill D.
• Douglas, John S.
• Quyyumi, Arshed A.
• Giddens, Don P.
• Veneziani, Alessandro
• Samady, Habib

Titel

Low Coronary Wall Shear Stress is Associated with Severe Endothelial Dysfunction in Patients with Non-Obstructive Coronary Artery Disease

Ist Teil von

• JACC. Cardiovascular interventions, 2018-09, Vol.11 (20), p.2072-2080

Erscheinungsjahr

2018

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• 44 patients with CAD underwent endothelial function testing. Segments with >10% vasoconstriction after acetylcholine (ACh) were defined as having severe EDFx. WSS, calculated using computational fluid dynamics, was defined as low (< 1 Pa), intermediate (1–2.5 Pa) or high (> 2.5 Pa). In 4,510 coronary segments, higher proportion of segments with low WSS had severe EDFx (71%) compared to intermediate WSS (22%) or high WSS (23%) (p < 0.001). Segments with low WSS demonstrated greater vasoconstriction in response to ACh than intermediate or high WSS segments (p < 0.001). Low WSS (OR: 9.14, p < 0.001) independently predicted severe EDFx.