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Genomic analysis of Lassa virus from the 2018 surge in Nigeria
Ist Teil von
The New England journal of medicine, 2018-10, Vol.379 (18), p.1745-1753
Ort / Verlag
Massachusetts Medical Society
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
In early 2018 Nigeria experienced an unprecedented increase in Lassa fever cases
with widespread geographic distribution. We report 77 Lassa virus genomes
generated from patient samples, 14 from 2018, to investigate whether recent
changes in the virus genome contributed to this surge. Our data argue that the
surge is not attributable to a single Lassa virus variant, nor has it been
sustained by human-to-human transmission. We observe extensive viral diversity
structured by geography, with major rivers appearing to act as barriers to
migration of the rodent reservoir. Together our results support that the 2018
Lassa fever surge was driven by crossspecies transmission from local rodent
populations of multiple viral variants from different lineages.