Details

Autor(en) / Beteiligte

• Haddock, Bryan Thomas
• Francis, Susan T
• Larsson, Henrik B W
• Andersen, Ulrik B

Titel

Assessment of Perfusion and Oxygenation of the Human Renal Cortex and Medulla by Quantitative MRI during Handgrip Exercise

Ist Teil von

• Journal of the American Society of Nephrology, 2018-10, Vol.29 (10), p.2510-2517

Ort / Verlag

United States: American Society of Nephrology

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity. To monitor medullary and cortical oxygenation under handgrip exercise-reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise. We used phase-contrast MRI to measure RAF, arterial spin labeling to measure perfusion, and both changes in transverse relaxation time (T *) and dynamic blood oxygenation level-dependent imaging to measure blood oxygenation. Handgrip exercise induced a significant decrease in RAF. In the renal medulla, this was accompanied by an increase of oxygenation (reflected by an increase in T *) despite a significant drop in medullary perfusion; the renal cortex showed a significant decrease in both perfusion and oxygenation. We also found a significant correlation ( =0.8) between resting systolic BP and the decrease in RAF during handgrip exercise. Renal MRI measurements in response to handgrip exercise were consistent with a sympathetically mediated decrease in RAF. In the renal medulla, oxygenation increased despite a reduction in perfusion, which we interpreted as the result of decreased GFR and a subsequently reduced reabsorptive workload. Our results further indicate that the renal flow response's sensitivity to sympathetic activation is correlated with resting BP, even within a normotensive range.