Details

Autor(en) / Beteiligte

• Bellin, Melena D
• Whitcomb, David C
• Abberbock, Judah
• Sherman, Stuart
• Sandhu, Bimaljit S
• Gardner, Timothy B
• Anderson, Michelle A
• Lewis, Michele D
• Alkaade, Samer
• Singh, Vikesh K
• Baillie, John
• Banks, Peter A
• Conwell, Darwin
• Cote, Gregory A
• Guda, Nalini M
• Muniraj, Thiruvengadam
• Tang, Gong
• Brand, Randall E
• Gelrud, Andres
• Amann, Stephen T
• Forsmark, Christopher E
• Wilcox, C Mel
• Slivka, Adam
• Yadav, Dhiraj

Titel

Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States

Ist Teil von

• The American journal of gastroenterology, 2017-09, Vol.112 (9), p.1457-1465

Ort / Verlag

United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP). Past studies for DM risk factors in CP have been limited to single centers or highly focused on a single etiology such as alcoholic or hereditary disease. We studied risk factors for DM in a large population of patients with CP of all etiologies enrolled in the North American Pancreatitis 2 studies. Participants (1,171) with CP (n=383 with DM, n=788 without DM) were enrolled prospectively from 26 participating centers. Questionnaires were completed by patients and physicians in a cross-sectional assessment. Patient demographics and disease characteristics were compared for CP with DM vs. without DM. Logistic regression was performed to assess the variables associated with DM diagnosis in a multivariable model. Diabetics were more likely to be black (P=0.02), overweight, or obese (P<0.001), and with a family history of DM (P=0.0005). CP patients with DM were more likely to have pancreatic calcifications (63% vs. 54%, P=0.002), atrophy (44% vs. 32%, P<0.0001), and prior pancreas surgery (26.9% vs. 16.9%, P<0.0001). In multivariate logistic regression modeling, the strongest risk factors for DM were obesity (odds ratio (OR) 2.8, 95% confidence interval (CI) 1.9, 4.2) and exocrine insufficiency (OR 2.4, 95% CI 1.8, 3.2). In this large multicenter cohort of patients with CP, exocrine insufficiency, calcifications, and pancreas surgery conveyed higher odds of having DM. However, the traditional 'type 2 DM' risk factors of obesity and family history were similarly important in conveying risk for DM.