Details

Autor(en) / Beteiligte

• Healey, Kelley R
• Kordalewska, Milena
• Jiménez Ortigosa, Cristina
• Singh, Ashutosh
• Berrío, Indira
• Chowdhary, Anuradha
• Perlin, David S

Titel

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

Ist Teil von

• Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Multiple Erg11 amino acid substitutions were identified in clinical isolates of originating from India and Colombia. Elevated azole MICs were detected in upon heterologous expression of alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs. Similar to other species, specific mutations resulted directly in reduced azole susceptibility.