World journal of gastroenterology : WJG, 2018-09, Vol.24 (34), p.3834-3848
2018
Details
- Autor(en) / Beteiligte
- Titel
- Drug resistance and new therapies in colorectal cancer
- Ist Teil von
- World journal of gastroenterology : WJG, 2018-09, Vol.24 (34), p.3834-3848
- Ort / Verlag
- United States: Baishideng Publishing Group Inc
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Colorectal cancer (CRC) is often diagnosed at an advanced stage when tumor cell dissemination has taken place. Chemo- and targeted therapies provide only a limited increase of overall survival for these patients. The major reason for clinical outcome finds its origin in therapy resistance. Escape mechanisms to both chemo- and targeted therapy remain the main culprits. Here, we evaluate major resistant mechanisms and elaborate on potential new therapies. Amongst promising therapies is α-amanitin antibody-drug conjugate targeting hemizygous p53 loss. It becomes clear that a dynamic interaction with the tumor microenvironment exists and that this dictates therapeutic outcome. In addition, CRC displays a limited response to checkpoint inhibitors, as only a minority of patients with microsatellite instable high tumors is susceptible. In this review, we highlight new developments with clinical potentials to augment responses to checkpoint inhibitors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1007-9327eISSN: 2219-2840DOI: 10.3748/wjg.v24.i34.3834Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6141340
- Format
- –
- Schlagworte
- Alpha-Amanitin - pharmacology, Alpha-Amanitin - therapeutic use, Antineoplastic Agents, Immunological - pharmacology, Antineoplastic Agents, Immunological - therapeutic use, Colorectal Neoplasms - drug therapy, Colorectal Neoplasms - genetics, Colorectal Neoplasms - immunology, Colorectal Neoplasms - mortality, Costimulatory and Inhibitory T-Cell Receptors - antagonists & inhibitors, Costimulatory and Inhibitory T-Cell Receptors - immunology, Drug Resistance, Neoplasm - drug effects, Drug Resistance, Neoplasm - genetics, Drug Resistance, Neoplasm - immunology, Humans, Immunoconjugates - pharmacology, Immunoconjugates - therapeutic use, Immunotherapy - methods, Microsatellite Instability - drug effects, Nucleic Acid Synthesis Inhibitors - pharmacology, Nucleic Acid Synthesis Inhibitors - therapeutic use, Review, RNA Polymerase II - antagonists & inhibitors, Treatment Outcome, Tumor Escape - drug effects, Tumor Escape - genetics, Tumor Escape - immunology, Tumor Microenvironment - drug effects, Tumor Microenvironment - immunology, Tumor Suppressor Protein p53 - genetics