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International journal of gynecological cancer, 2018-03, Vol.28 (3), p.500-504
2018
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Details

Autor(en) / Beteiligte
Titel
Female Sex Hormone Receptor Profiling in Uterine Adenosarcomas
Ist Teil von
  • International journal of gynecological cancer, 2018-03, Vol.28 (3), p.500-504
Ort / Verlag
England: by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology
Erscheinungsjahr
2018
Quelle
MEDLINE
Beschreibungen/Notizen
  • OBJECTIVEThis study aimed to identify the hormonal receptor status in uterine adenosarcoma (AS) and uterine AS with sarcomatous overgrowth (AS + SO), including those with high-grade histologic features (nuclear pleomorphism, atypical mitoses, necrosis), with or without heterologous elements. Estrogen receptor (ER) status, including estrogen receptor α (ERα), estrogen receptor β (ERβ), and G protein–coupled estrogen receptor (GPER), and progesterone receptor (PgR) status were examined. METHODSFrom August 2001 to November 2013, 11 patients with histologic diagnosis of uterine AS were identified. Tumor tissue sections were stained for ERα, ERβ, GPER, and PgR and examined both for percentage of overall cells stained and for intensity of staining. Descriptive statistics were calculated using clinicopathologic data abstracted from the medical record. RESULTSEight cases of AS and 3 cases of AS with high-grade features were identified. Seven of 8 tumor samples of AS showed strong or moderate intensity immunostaining for ERα; all AS + SO tumor samples showed minimal to no immunoreactivity for ERα. There was a significant decrease in ERα H scores in high-grade tumors when compared with AS (P = 0.01). Lower PgR H scores were observed in high-grade tumors compared with those in AS (P = 0.04). Estrogen receptor β immunostaining was variable, and GPER immunostaining was absent in the majority of tumor samples. CONCLUSIONSHigher expression of ERα and PgR was observed in AS when compared with those with AS + SO and high-grade features. Both tumor subtypes showed similar levels of ERβ and GPER expression, although significant differences in ERβ and GPER expression were not detected. In contrast to our previous findings in uterine carcinosarcoma, ERs ERβ and GPER do not seem to play a significant role in AS in this study.
Sprache
Englisch
Identifikatoren
ISSN: 1048-891X
eISSN: 1525-1438
DOI: 10.1097/IGC.0000000000001183
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6125779

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