Details

Autor(en) / Beteiligte

• Goldsmith, David R.
• Haroon, Ebrahim
• Miller, Andrew H.
• Strauss, Gregory P.
• Buckley, Peter F.
• Miller, Brian J.

Titel

TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia

Ist Teil von

• Schizophrenia research, 2018-09, Vol.199, p.281-284

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. We measured inflammatory markers in patients with and without deficit schizophrenia and controls. Using multivariate analyses, tumor necrosis factor (TNF)-α and interleukin-6 were associated with the deficit syndrome, and TNF-α predicted blunted affect, alogia, and total negative symptoms. Findings suggest that deficit schizophrenia subtype is associated with increased inflammation and immunotherapies may be a novel target for negative symptoms.