Details

Autor(en) / Beteiligte

• MacFarland, Suzanne P.
• Duffy, Kelly A.
• Bhatti, Tricia R.
• Bagatell, Rochelle
• Balamuth, Naomi J.
• Brodeur, Garrett M.
• Ganguly, Arupa
• Mattei, Peter A.
• Surrey, Lea F.
• Balis, Frank M.
• Kalish, Jennifer M.

Titel

Diagnosis of Beckwith–Wiedemann syndrome in children presenting with Wilms tumor

Ist Teil von

• Pediatric blood & cancer, 2018-10, Vol.65 (10), p.e27296-n/a

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Beckwith–Wiedemann syndrome (BWS) is a genetic syndrome associated with overgrowth and cancer predisposition, including predisposition to Wilms tumor (WT). Patients with BWS and BWS spectrum are screened from birth to age 7 years for BWS‐associated cancers. However, in some cases a BWS‐associated cancer may be the first recognized manifestation of the syndrome. We describe 12 patients diagnosed with BWS after presenting with a WT. We discuss the features of BWS in these patients and hypothesize that earlier detection of BWS by attention to its subtler manifestations could lead to earlier detection of children at risk for associated malignancies.