Details

Autor(en) / Beteiligte

• Ajmera, Veeral
• Park, Charlie C.
• Caussy, Cyrielle
• Singh, Seema
• Hernandez, Carolyn
• Bettencourt, Ricki
• Hooker, Jonathan
• Sy, Ethan
• Behling, Cynthia
• Xu, Ronghui
• Middleton, Michael S.
• Valasek, Mark A.
• Faulkner, Claire
• Rizo, Emily
• Richards, Lisa
• Sirlin, Claude B.
• Loomba, Rohit

Titel

Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 2018-08, Vol.155 (2), p.307-310.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Markers are needed to predict progression of nonalcoholic fatty liver disease (NAFLD). The proton density fat fraction, measured by magnetic resonance imaging (MRI-PDFF), provides an accurate, validated marker of hepatic steatosis; however, it is not clear whether the PDFF identifies patients at risk for NAFLD progression. We performed a follow-up study of 95 well-characterized patients with biopsy-proven NAFLD and examined the association between liver fat content and fibrosis progression. MRI-PDFF measurements were made at study entry (baseline). Biopsies were collected from patients at baseline and after a mean time period of 1.75 years. Among patients with no fibrosis at baseline, a higher proportion of patients in the higher liver fat group (MRI-PDFF ≥15.7%) had fibrosis progression (38.1%) than in the lower liver fat group (11.8%) (P = .067). In multivariable-adjusted logistic regression models (adjusted for age, sex, ethnicity, and body mass index), patients in the higher liver fat group had a significantly higher risk of fibrosis progression (multivariable-adjusted odds ratio 6.7; 95% confidence interval 1.01–44.1; P = .049). Our findings associate higher liver fat content, measured by MRI-PDFF, with fibrosis progression. [Display omitted]