Details

Autor(en) / Beteiligte

• Kim, Young-In
• Song, Joo-Hye
• Ko, Hyun-Jeong
• Kweon, Mi-Na
• Kang, Chang-Yuil
• Reinecker, Hans-Christian
• Chang, Sun-Young

Titel

CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production

Ist Teil von

• The Journal of immunology (1950), 2018-08, Vol.201 (4), p.1287-1294

Ort / Verlag

Baltimore: American Association of Immunologists

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c+CX3CR1+CD64+ macrophages in IgA production in the intestine. Intestinal CX3CR1+ macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX3CR1+ macrophages specifically induced intestinal IgA production. The induction of IgA by CX3CR1+ macrophages required BAFF, a proliferation-inducing ligand, and TNF-α, but was surprisingly independent of TLR-mediated microbial recognition and retinoic acid signaling. IgA secretion by CX3CR1+ macrophages was enhanced by LP CD8+ T cells through the secretion of IL-9 and IL-13. CX3CR1+ macrophages and CD8+ T cells induced IgA production by B cells independently of mesenteric lymph nodes and Peyer patches. Our data reveal a previously unrecognized cellular circuitry in which LP CX3CR1+ macrophages, B cells, and CD8+ T cells coordinate the protective Ig secretion in the small intestine upon peripheral Ag delivery.