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Human molecular genetics, 2018-08, Vol.27 (R2), p.R108-R118
2018
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Autor(en) / Beteiligte
Titel
Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease
Ist Teil von
  • Human molecular genetics, 2018-08, Vol.27 (R2), p.R108-R118
Ort / Verlag
England: Oxford University Press
Erscheinungsjahr
2018
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
  • Abstract The notion that one common pathogenic pathway could account for the various clinically distinguishable, typically late-onset neurodegenerative diseases might appear unlikely given the plethora of diverse primary causes of neurodegeneration. On the contrary, an autoinflammatory pathogenic mechanism allows diverse genetic and environmental factors to converge into a common chain of causality. Inflammation has long been known to correlate with neurodegeneration. Until recently this relationship was seen as one of consequence rather than cause-with inflammatory cells and events acting to 'clean up the mess' after neurological injury. This explanation is demonstrably inadequate and it is now clear that inflammation is at the very least, rate-limiting for neurodegeneration (and more likely, a principal underlying cause in most if not all neurodegenerative diseases), protective in its initial acute phase, but pernicious in its latter chronic phase.
Sprache
Englisch
Identifikatoren
ISSN: 0964-6906
eISSN: 1460-2083
DOI: 10.1093/hmg/ddy139
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6061832

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