Details

Autor(en) / Beteiligte

• Drown, Bryon S.
• Hergenrother, Paul J.

Titel

Going on offense against the gram-negative defense

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.6530-6532

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Drown and Hergenrother cite that bacterial infections resistant to antibiotics are becoming more common, posing a significant health risk. The CDC and WHO have identified gram-negative drug-resistant pathogens as being particularly dangerous, and such infections are resistant to nearly all available antibiotics in some cases. The most concerning of these infections are three classes of nonfastidious gram-negative pathogens, Enterobacteriaceae (including Escherichia coli and Klebsiella pneumonia), Pseudomonas aeruginosa, and Acinetobacter baumannii. As only nine classes of antibiotics (that engage five targets) are available for the treatment of these infections, the need for new classes of antibiotics effective against gram-negative bacteria is self-evident.