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Going on offense against the gram-negative defense
Ist Teil von
Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.6530-6532
Ort / Verlag
United States: National Academy of Sciences
Erscheinungsjahr
2018
Quelle
MEDLINE
Beschreibungen/Notizen
Drown and Hergenrother cite that bacterial infections resistant to antibiotics are becoming more common, posing a significant health risk. The CDC and WHO have identified gram-negative drug-resistant pathogens as being particularly dangerous, and such infections are resistant to nearly all available antibiotics in some cases. The most concerning of these infections are three classes of nonfastidious gram-negative pathogens, Enterobacteriaceae (including Escherichia coli and Klebsiella pneumonia), Pseudomonas aeruginosa, and Acinetobacter baumannii. As only nine classes of antibiotics (that engage five targets) are available for the treatment of these infections, the need for new classes of antibiotics effective against gram-negative bacteria is self-evident.