Details

Autor(en) / Beteiligte

• Sethi, Vrishketan
• Kurtom, Saba
• Tarique, Mohammad
• Lavania, Shweta
• Malchiodi, Zoe
• Hellmund, Leonor
• Zhang, Li
• Sharma, Umakant
• Giri, Bhuwan
• Garg, Bharti
• Ferrantella, Anthony
• Vickers, Selwyn M.
• Banerjee, Sulagna
• Dawra, Rajinder
• Roy, Sabita
• Ramakrishnan, Sundaram
• Saluja, Ashok
• Dudeja, Vikas

Titel

Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 2018-07, Vol.155 (1), p.33-37.e6

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma–producing T cells with corresponding decrease in interleukin 17A and interleukin 10–producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.