The New England journal of medicine, 2018-02, Vol.378 (5), p.439-448
- Maude, Shannon L
- Laetsch, Theodore W
- Buechner, Jochen
- Rives, Susana
- Boyer, Michael
- Bittencourt, Henrique
- Bader, Peter
- Verneris, Michael R
- Stefanski, Heather E
- Myers, Gary D
- Qayed, Muna
- De Moerloose, Barbara
- Hiramatsu, Hidefumi
- Schlis, Krysta
- Davis, Kara L
- Martin, Paul L
- Nemecek, Eneida R
- Yanik, Gregory A
- Peters, Christina
- Baruchel, Andre
- Boissel, Nicolas
- Mechinaud, Francoise
- Balduzzi, Adriana
- Krueger, Joerg
- June, Carl H
- Levine, Bruce L
- Wood, Patricia
- Taran, Tetiana
- Leung, Mimi
- Mueller, Karen T
- Zhang, Yiyun
- Sen, Kapildeb
- Lebwohl, David
- Pulsipher, Michael A
- Grupp, Stephan A
2018
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Details
- Autor(en) / Beteiligte
- Maude, Shannon L
- Laetsch, Theodore W
- Buechner, Jochen
- Rives, Susana
- Boyer, Michael
- Bittencourt, Henrique
- Bader, Peter
- Verneris, Michael R
- Stefanski, Heather E
- Myers, Gary D
- Qayed, Muna
- De Moerloose, Barbara
- Hiramatsu, Hidefumi
- Schlis, Krysta
- Davis, Kara L
- Martin, Paul L
- Nemecek, Eneida R
- Yanik, Gregory A
- Peters, Christina
- Baruchel, Andre
- Boissel, Nicolas
- Mechinaud, Francoise
- Balduzzi, Adriana
- Krueger, Joerg
- June, Carl H
- Levine, Bruce L
- Wood, Patricia
- Taran, Tetiana
- Leung, Mimi
- Mueller, Karen T
- Zhang, Yiyun
- Sen, Kapildeb
- Lebwohl, David
- Pulsipher, Michael A
- Grupp, Stephan A
- Titel
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- Ist Teil von
- The New England journal of medicine, 2018-02, Vol.378 (5), p.439-448
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- CD19-specific CAR T cells were produced centrally for a global study in young people with relapsed B-cell ALL. The overall remission rate was 81%, and patients with a response were negative for minimal residual disease. High-grade toxic effects were frequent but treatable.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1709866Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5996391
- Format
- –
- Schlagworte
- Acute lymphoblastic leukemia, Adolescent, Antibodies, Monoclonal, Humanized - administration & dosage, Antigens, CD19, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Bone marrow, Cancer, Care and treatment, CD19 antigen, Child, Child, Preschool, Children, Children & youth, Chimeric antigen receptors, Comparative analysis, Edema, Female, Flow cytometry, Health aspects, Hematology, Humans, Infusions, Intravenous, Leukemia, Lymphatic leukemia, Lymphocytes B, Lymphocytes T, Lymphocytic leukemia, Male, Medical research, Minimal residual disease, Monoclonal antibodies, Oncology, Pediatrics, Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality, Receptors, Antigen, T-Cell - antagonists & inhibitors, Receptors, Antigen, T-Cell - therapeutic use, Remission, Remission Induction, Stem cells, Survival Analysis, Transplants & implants, Treatment outcome, Young Adult, Young adults