Details

Autor(en) / Beteiligte

• Baba, Akira
• Goto, Tazuko K
• Ojiri, Hiroya
• Takagiwa, Mutsumi
• Hiraga, Chiho
• Okamura, Masahiro
• Hasegawa, Sho
• Okuyama, Yumi
• Ogino, Nobuhiro
• Yamauchi, Hideomi
• Kobashi, Yuko
• Yamazoe, Shinji
• Munetomo, Yohei
• Mogami, Takuji
• Nomura, Takeshi

Titel

CT imaging features of antiresorptive agent-related osteonecrosis of the jaw/medication-related osteonecrosis of the jaw

Ist Teil von

• Dento-maxillo-facial radiology, 2018-05, Vol.47 (4), p.20170323-20170323

Ort / Verlag

England: The British Institute of Radiology

Erscheinungsjahr

2018

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Antiresorptive agent-related osteonecrosis of the jaw (ARONJ)/medication-related osteonecrosis of the jaw (MRONJ) include both bisphosphonate-related osteonecrosis of jaw (BRONJ) and denosumab-related osteonecrosis of jaw (DRONJ). The purpose of this study is to study radiological characteristics of ARONJ/MRONJ. These imaging features may serve as one useful aid for assessing ARONJ/MRONJ. CT scans of 74 Japanese patients, who were clinically diagnosed by inclusion criteria of ARONJ/MRONJ, obtained between April 1, 2011 and September 30, 2016, were evaluated. We investigated the CT imaging features of ARONJ/MRONJ, and clarified radiological differentiation between BRONJ and DRONJ, BRONJ due to oral bisphosphonate administration and due to intravenous bisphosphonate administration, BRONJ with respective kinds of medication, BRONJ with long-term administration and short-term administration, BRONJ with each clinical staging respectively. Fisher's exact test, χ test, Student's t-test and analysis of variance were performed in the statistical analyses. Unilateral maxillary sinusitis was detected in all patients with upper ARONJ/MRONJ (100%). DRONJ showed large sequestrum more frequently than BRONJ (3/4, 75 vs 3/35, 8.6%, p < 0.05). DRONJ showed periosteal reaction more frequently than BRONJ (4/10, 40 vs 7/65, 10.1%, p < 0.05). Patients of BRONJ resulting from intravenous bisphosphonate administration showed larger and more frequent buccolingual cortical bone perforations than BRONJ resulting from oral bisphosphonate administration (7/8, 87.5 vs 11/30, 36.7%, p < 0.05). There was no significant correlation between CT findings and respective kinds of medication, long/short-term administration, clinical stages of BRONJ. ARONJ/MRONJ has characteristic CT image findings which could be useful for its assessment.