Details

Autor(en) / Beteiligte

• Artap, Stanley
• Manderfield, Lauren J.
• Smith, Cheryl L.
• Poleshko, Andrey
• Aghajanian, Haig
• See, Kelvin
• Li, Li
• Jain, Rajan
• Epstein, Jonathan A.

Titel

Endocardial Hippo signaling regulates myocardial growth and cardiogenesis

Ist Teil von

• Developmental biology, 2018-08, Vol.440 (1), p.22-30

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The Hippo signaling pathway has been implicated in control of cell and organ size, proliferation, and endothelial-mesenchymal transformation. This pathway impacts upon two partially redundant transcription cofactors, Yap and Taz, that interact with other factors, including members of the Tead family, to affect expression of downstream genes. Yap and Taz have been shown to regulate, in a cell-autonomous manner, myocardial proliferation, myocardial hypertrophy, regenerative potential, and overall size of the heart. Here, we show that Yap and Taz also play an instructive, non-cell-autonomous role in the endocardium of the developing heart to regulate myocardial growth through release of the paracrine factor, neuregulin. Without endocardial Yap and Taz, myocardial growth is impaired causing early post-natal lethality. Thus, the Hippo signaling pathway regulates cell size via both cell-autonomous and non-cell-autonomous mechanisms. Furthermore, these data suggest that Hippo may regulate organ size via a sensing and paracrine function in endothelial cells. •Non-cell autonomous Hippo signaling regulates myocardial growth and organ size.•Myocardial development requires Yap/Taz-dependent regulation of endocardial Nrg1.•Yap/Taz regulate myocardial growth through release of the paracrine factor, Nrg1.