Details

Autor(en) / Beteiligte

• Ruiz-Canela, Miguel
• Guasch-Ferré, Marta
• Toledo, Estefanía
• Clish, Clary B.
• Razquin, Cristina
• Liang, Liming
• Wang, Dong D.
• Corella, Dolores
• Estruch, Ramón
• Hernáez, Álvaro
• Yu, Edward
• Gómez-Gracia, Enrique
• Zheng, Yan
• Arós, Fernando
• Romaguera, Dora
• Dennis, Courtney
• Ros, Emilio
• Lapetra, José
• Serra-Majem, Lluis
• Papandreou, Christopher
• Portoles, Olga
• Fitó, Montserrat
• Salas-Salvadó, Jordi
• Hu, Frank B.
• Martínez-González, Miguel A.

Titel

Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial

Ist Teil von

• Diabetologia, 2018-07, Vol.61 (7), p.1560-1571

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2018

Quelle

SpringerLink

Beschreibungen/Notizen

• Aims/hypothesis Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil ( n  = 273), a MedDiet+nuts ( n  = 324) or a control diet ( n  = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups ( p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention ( p =  0.005 vs the control group). Conclusions/interpretation Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number : SRCTN35739639 ( www.controlled-trials.com )