Details

Autor(en) / Beteiligte

• Jackson, Daniel J
• Bacharier, Leonard B
• Mauger, David T
• Boehmer, Susan
• Beigelman, Avraham
• Chmiel, James F
• Fitzpatrick, Anne M
• Gaffin, Jonathan M
• Morgan, Wayne J
• Peters, Stephen P
• Phipatanakul, Wanda
• Sheehan, William J
• Cabana, Michael D
• Holguin, Fernando
• Martinez, Fernando D
• Pongracic, Jacqueline A
• Baxi, Sachin N
• Benson, Mindy
• Blake, Kathryn
• Covar, Ronina
• Gentile, Deborah A
• Israel, Elliot
• Krishnan, Jerry A
• Kumar, Harsha V
• Lang, Jason E
• Lazarus, Stephen C
• Lima, John J
• Long, Dayna
• Ly, Ngoc
• Marbin, Jyothi
• Moy, James N
• Myers, Ross E
• Olin, J. Tod
• Raissy, Hengameh H
• Robison, Rachel G
• Ross, Kristie
• Sorkness, Christine A
• Lemanske, Robert F

Titel

Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations

Ist Teil von

• The New England journal of medicine, 2018-03, Vol.378 (10), p.891-901

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Inhaled glucocorticoids may prevent a mild loss of asthma control from becoming a full exacerbation. In a randomized trial involving children, quintupling the daily dose at early signs of loss of asthma control did not result in a lower rate of severe asthma exacerbations. Increases in symptoms may occur before exacerbations fully develop. In two trials, when symptoms occurred, the dose of inhaled glucocorticoids was increased by a factor of 5 (pediatric trial) or 4 (adult trial). There was no benefit, and perhaps some harm, in children, and a modest benefit in adults.