Details

Autor(en) / Beteiligte

• Hodges, Kyndall
• Brewer, Sheridan S.
• Labbé, Catherine
• Soto-Ortolaza, Alexandra I.
• Walton, Ronald L.
• Strongosky, Audrey J.
• Uitti, Ryan J.
• van Gerpen, Jay A.
• Ertekin-Taner, Nilüfer
• Kantarci, Kejal
• Lowe, Val J.
• Parisi, Joseph E.
• Savica, Rodolfo
• Graff-Radford, Jonathan
• Jones, David T.
• Knopman, David S.
• Petersen, Ronald C.
• Murray, Melissa E.
• Graff-Radford, Neill R.
• Ferman, Tanis J.
• Dickson, Dennis W.
• Wszolek, Zbigniew K.
• Boeve, Bradley F.
• Ross, Owen A.
• Lorenzo-Betancor, Oswaldo

Titel

RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies

Ist Teil von

• Neurobiology of aging, 2016-09, Vol.45, p.107-108

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Mutations in Ras-related protein Rab-39B (RAB39B) gene have been linked to X-linked early-onset Parkinsonism with intellectual disabilities. The aim of this study was to address the genetic contribution of RAB39B to Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pathologically confirmed Lewy body dementia (pLBD) cases. A cohort of 884 PD, 399 DLB, and 379 pLBD patients were screened for RAB39B mutations, but no coding variants were found, suggesting RAB39B mutations are not a common cause of PD, DLB, or pLBD in Caucasian population.