Current opinion in immunology, 2013-06, Vol.25 (3), p.381-388
2013
Details
- Autor(en) / Beteiligte
- Titel
- Manipulating the PD-1 pathway to improve immunity
- Ist Teil von
- Current opinion in immunology, 2013-06, Vol.25 (3), p.381-388
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Blocking PD-1 signaling rescues exhausted T cells in chronic infections and cancer. • PD-1 pathway blockade unleashes effector T cell functions on target cells. • Combining PD-1 pathway blockade to therapeutic vaccination improves T cell rescue. • PD-1 pathway may regulate humoral immunity, but mechanisms are not well established. • Further studies on how PD-1 modulates initiation of immune responses are needed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0952-7915eISSN: 1879-0372DOI: 10.1016/j.coi.2013.03.003Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5946314