Details

Autor(en) / Beteiligte

• Dixon-Suen, Suzanne C
• Nagle, Christina M
• Thrift, Aaron P
• Pharoah, Paul D P
• Pearce, Celeste Leigh
• Zheng, Wei
• Fasching, Peter A
• Beckmann, Matthias W
• Lambrechts, Diether
• Vergote, Ignace
• Rossing, Mary Anne
• Doherty, Jennifer A
• Chang-Claude, Jenny
• Moysich, Kirsten B
• Odunsi, Kunle
• Goodman, Marc T
• Wilkens, Lynne R
• Thompson, Pamela J
• Shvetsov, Yurii B
• Dörk, Thilo
• Park-Simon, Tjoung-Won
• Hillemanns, Peter
• Bogdanova, Natalia
• Butzow, Ralf
• Nevanlinna, Heli
• Pelttari, Liisa M
• Leminen, Arto
• Modugno, Francesmary
• Ness, Roberta B
• Edwards, Robert P
• Kelley, Joseph L
• Heitz, Florian
• du Bois, Andreas
• Schwaab, Ira
• Karlan, Beth Y
• Lester, Jenny
• Orsulic, Sandra
• Rimel, Bobbie J
• Kjær, Susanne K
• Høgdall, Estrid
• Jensen, Allan
• Goode, Ellen L
• Fridley, Brooke L
• Cunningham, Julie M
• Winham, Stacey J
• Giles, Graham G
• Southey, Melissa C
• Hildebrandt, Michelle A T
• Wu, Xifeng
• Lu, Karen H
• Liang, Dong
• Levine, Douglas A
• Schildkraut, Joellen M
• Berchuck, Andrew
• Cramer, Daniel W
• Terry, Kathryn L
• Bandera, Elisa V
• Olson, Sara H
• Salvesen, Helga B
• Thomsen, Liv Cecilie Vestrheim
• Kopperud, Reidun K
• Bjorge, Line
• Bruegl, Amanda
• Cook, Linda S
• Le, Nhu D
• Swenerton, Kenneth D
• Brooks-Wilson, Angela
• Kelemen, Linda E
• Lubiński, Jan
• Huzarski, Tomasz
• Gronwald, Jacek
• Menkiszak, Janusz
• Wentzensen, Nicolas
• Brinton, Louise
• Yang, Hannah
• Lissowska, Jolanta
• Høgdall, Claus K
• Lundvall, Lene
• Song, Honglin
• Tyrer, Jonathan P
• Campbell, Ian
• Glasspool, Rosalind
• Siddiqui, Nadeem
• Whittemore, Alice S
• Sieh, Weiva
• McGuire, Valerie
• Rothstein, Joseph H
• Narod, Steven A
• Risch, Harvey A
• McLaughlin, John R
• Menon, Usha
• Gayther, Simon A
• Gentry-Maharaj, Aleksandra
• Wu, Anna H
• Pike, Malcolm C
• Kupryjanczyk, Jolanta
• Dansonka-Mieszkowska, Agnieszka
• Budzilowska, Agnieszka
• Rzepecka, Iwona K
• Webb, Penelope M

Titel

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Ist Teil von

• British journal of cancer, 2018-04, Vol.118 (8), p.1123-1129

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.