Details

Autor(en) / Beteiligte

• Cloyd, Jordan M.
• Omichi, Kiyohiko
• Mizuno, Takashi
• Kawaguchi, Yoshikuni
• Tzeng, Ching-Wei D.
• Conrad, Claudius
• Chun, Yun Shin
• Aloia, Thomas A.
• Katz, Matthew H. G.
• Lee, Jeffrey E.
• Halperin, Daniel
• Yao, James
• Vauthey, Jean-Nicolas
• Dasari, Arvind

Titel

Preoperative Fluorouracil, Doxorubicin, and Streptozocin for the Treatment of Pancreatic Neuroendocrine Liver Metastases

Ist Teil von

• Annals of surgical oncology, 2018-06, Vol.25 (6), p.1709-1715

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Introduction While preoperative chemotherapy is frequently utilized before resection of non-neuroendocrine liver metastases, patients with resectable neuroendocrine liver metastases typically undergo surgery first. FAS is a cytotoxic chemotherapy regimen that is associated with substantial response rates in locally advanced and metastatic pancreatic neuroendocrine tumors. Methods All patients who underwent R0/R1 resection of pancreatic neuroendocrine liver metastases at a single institution between 1998 and 2015 were included. The outcomes of patients treated with preoperative FAS were compared with those of patients who were not. Results Of the 67 patients included, 27 (40.3%) received preoperative FAS, whereas 40 (59.7%) did not. Despite being associated with higher rates of synchronous disease, lymph node metastases, and larger tumor size, patients who received preoperative FAS had similar overall survival [overall survival (OS), 108.2 months (95% confidence interval (CI) 78.0–136.0) vs. 107.0 months (95% CI 78.0–136.0), p  = 0.64] and recurrence-free survival [RFS, 25.1 months (95% CI 23.2–27.0) vs. 18.0 months (95% CI 13.8–22.2), p  = 0.16] as patients who did not. Among patients who presented with synchronous liver metastases ( n  = 46), the median OS [97.3 months (95% CI 65.9–128.6) vs. 65.0 months (95% CI 28.1–101.9), p  = 0.001] and RFS [24.8 months (95% CI 22.6–26.9) vs. 12.1 months (2.2–22.0), p  = 0.003] were significantly greater among patients who received preoperative FAS compared with those who did not. Conclusions The use of FAS before liver resection is associated with improved OS compared with surgery alone among patients with advanced synchronous pancreatic neuroendocrine liver metastases.