Details

Autor(en) / Beteiligte

• Sainato, Rebecca
• ElGendy, Atef
• Poly, Frédéric
• Kuroiwa, Janelle
• Guerry, Patricia
• Riddle, Mark S
• Porter, Chad K

Titel

Epidemiology of Campylobacter Infections among Children in Egypt

Ist Teil von

• The American journal of tropical medicine and hygiene, 2018-01, Vol.98 (2), p.581-585

Ort / Verlag

United States: Institute of Tropical Medicine

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• is a frequently isolated bacterial pathogen among children with diarrhea. Data are lacking on the distribution and spectrum of disease associated with species and capsular polysaccharide (CPS) types. This information is essential because current vaccine research seeks to target specific CPS types. An effective CPS-conjugate vaccine will need to cover CPS types that are both common and associated with severe disease. The US Naval Medical Research Unit-3 conducted several prospective cohort studies researching diarrheal disease in Egypt from 1995 to 2003. In total, 1,057 children were enrolled and followed to a maximum age of 36 months. We analyzed -positive stool samples that were collected while subjects were symptomatic, along with corresponding clinical data. Of 441 isolates, 322 represented primary infections (189 , 127 , six unspeciated). There were 19 CPS types identified; eight accounted for 63.5% of primary infections. We also screened for the presence of the type-6 secretion system (T6SS), a putative virulence determinant. The T6SS was found in 18.0% of isolates and 57.6% of isolates ( < 0.001), and was not uniformly distributed among CPS types ( < 0.001). Strains with the T6SS were not associated with more severe disease. Clinical presentations across species and CPS types appeared similar. This study adds to the growing epidemiological data and also provides some analysis of the clinical spectrum associated with infection by specific species, capsule types, and possible virulence determinants.