Details

Autor(en) / Beteiligte

• Savage, Jessica H.
• Lee‐Sarwar, Kathleen A.
• Sordillo, Joanne
• Bunyavanich, Supinda
• Zhou, Yanjiao
• O'Connor, George
• Sandel, Megan
• Bacharier, Leonard B.
• Zeiger, Robert
• Sodergren, Erica
• Weinstock, George M.
• Gold, Diane R.
• Weiss, Scott T.
• Litonjua, Augusto A.

Titel

A prospective microbiome‐wide association study of food sensitization and food allergy in early childhood

Ist Teil von

• Allergy (Copenhagen), 2018-01, Vol.73 (1), p.145-152

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. Methods Intestinal microbiome samples were collected at age 3‐6 months in children participating in the follow‐up phase of an interventional trial of high‐dose vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food allergy was defined as caretaker report of healthcare provider‐diagnosed allergy to the above foods prior to age 3 with evidence of IgE sensitization. Analysis was performed using Phyloseq and DESeq2; P‐values were adjusted for multiple comparisons. Results Complete data were available for 225 children; there were 87 cases of food sensitization and 14 cases of food allergy. Microbial diversity measures did not differ between food sensitization and food allergy cases and controls. The genera Haemophilus (log2 fold change −2.15, P=.003), Dialister (log2 fold change −2.22, P=.009), Dorea (log2 fold change −1.65, P=.02), and Clostridium (log2 fold change −1.47, P=.002) were underrepresented among subjects with food sensitization. The genera Citrobacter (log2 fold change −3.41, P=.03), Oscillospira (log2 fold change −2.80, P=.03), Lactococcus (log2 fold change −3.19, P=.05), and Dorea (log2 fold change −3.00, P=.05) were underrepresented among subjects with food allergy. Conclusions The temporal association between bacterial colonization and food sensitization and allergy suggests that the microbiome may have a causal role in the development of food allergy. Our findings have therapeutic implications for the prevention and treatment of food allergy.