Details

Autor(en) / Beteiligte

• Chacko, Kieran I
• Sullivan, Mitchell J
• Beckford, Colleen
• Altman, Deena R
• Ciferri, Brianne
• Pak, Theodore R
• Sebra, Robert
• Kasarskis, Andrew
• Hamula, Camille L
• van Bakel, Harm

Titel

Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia

Ist Teil von

• Antimicrobial agents and chemotherapy, 2018-04, Vol.62 (4)

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Whole-genome sequencing was used to examine a persistent bacteremia that acquired heteroresistance to three antibiotics in response to prolonged multidrug therapy. A comparison of the complete genomes before and after each change revealed the emergence of known resistance determinants for vancomycin and linezolid and suggested that a novel mutation in , encoding a fatty acid synthase, was responsible for daptomycin nonsusceptibility. Plasmid recombination contributed to the progressive loss of vancomycin resistance after withdrawal of the drug.