Details

Autor(en) / Beteiligte

• Suwunnakorn, Sumanun
• Wakabayashi, Hironao
• Kordalewska, Milena
• Perlin, David S
• Rustchenko, Elena

Titel

FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility

Ist Teil von

• Antimicrobial agents and chemotherapy, 2018-04, Vol.62 (4)

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2018

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• , a prevailing opportunistic fungal pathogen of humans, has a diploid genome containing three homologous genes that are evolutionarily conserved. One of these, the essential gene , encodes the catalytic subunit of glucan synthase, which is the target of echinocandin drugs and also serves as a site of drug resistance. The other two glucan synthase-encoding genes, and , are also expressed, but their roles in resistance are considered unimportant. However, we report here that expression of is upregulated in strains lacking either or Furthermore, in contrast to what is observed in heterozygous deletion strains, cells lacking or contain increased amounts of cell wall glucan, are more resistant to echinocandin drugs, and consistently are tolerant to cell wall-damaging agents. Our data indicate that and can act as negative regulators of , thereby influencing echinocandin susceptibility.