Details

Autor(en) / Beteiligte

• Blacque, Oliver E
• Scheidel, Noemie
• Kuhns, Stefanie

Titel

Rab GTPases in cilium formation and function

Ist Teil von

• Small GTPases, 2018-03, Vol.9 (1-2), p.76-94

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2018

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Cilia are microtubule-based organelles extending from a basal body at the surface of eukaryotic cells. Cilia regulate cell and fluid motility, sensation and developmental signaling, and ciliary defects cause human diseases (ciliopathies) affecting the formation and function of many tissues and organs. Over the past decade, various Rab and Rab-like membrane trafficking proteins have been shown to regulate cilia-related processes such as basal body maturation, ciliary axoneme extension, intraflagellar transport and ciliary signaling. In this review, we provide a comprehensive overview of Rab protein ciliary associations, drawing on findings from multiple model systems, including mammalian cell culture, mice, zebrafish, C. elegans, trypanosomes, and green algae. We also discuss several emerging mechanistic themes related to ciliary Rab cascades and functional redundancy.